The objective of this work was to develop sustained release formulation of famotidine by using polymers (guar gum and hupu gum). Six formulations of sustained release matrix granules were prepared by wet granulation method, in the ratios of (1:1, 1:1.5, 1:2). The prepared granules were evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. 50 mg of famotidine granules were accurately weighed and these granules are filled in to capsules. These capsules are hard gelatin capsule shells, are made up of gelatin, sugar and water. Generally, they are clear, colorless and tasteless. Gelatin is the main material of these capsules due to its excellent characteristic as a gelatinizer. In-vitro studies revealed that famotidine formulation with hupu gum was able to sustain the drug release for 8 hours (95.1±0.83). Fitting the in-vitro release data to kinetic analysis, the best fit release kinetics was achieved in peppas and zero order. Results of the present study indicated that famotidine capsules filled with matrix granules can be delivered successfully as sustained release formulation.
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